Fast inhibition of glutamate-activated currents by caffeine.
Caffeine stimulates calcium-induced calcium release (CICR) in many cell types.In neurons, caffeine stimulates CICR presynaptically and thus modulates neurotransmitter release.Using the whole-cell patch-clamp technique we found that caffeine (20 mM) reversibly increased the frequency and decreased the amplitude of miniature excitatory postsynaptic c